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2 Janelia Publications

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    03/02/20 | Kilohertz two-photon fluorescence microscopy imaging of neural activity in vivo.
    Wu J, Liang Y, Chen S, Hsu C, Chavarha M, Evans SW, Shi D, Lin MZ, Tsia KK, Ji N
    Nature Methods. 2020 Mar 02;17(3):287-290. doi: 10.1038/s41592-020-0762-7

    Understanding information processing in the brain requires monitoring neuronal activity at high spatiotemporal resolution. Using an ultrafast two-photon fluorescence microscope empowered by all-optical laser scanning, we imaged neuronal activity in vivo at up to 3,000 frames per second and submicrometer spatial resolution. This imaging method enabled monitoring of both supra- and subthreshold electrical activity down to 345 μm below the brain surface in head-fixed awake mice.

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    03/02/20 | Rapid mesoscale volumetric imaging of neural activity with synaptic resolution.
    Lu R, Liang Y, Meng G, Zhou P, Svoboda K, Paninski L, Ji N
    Nature Methods. 2020 Mar 02;17(3):291-4. doi: 10.1038/s41592-020-0760-9

    Imaging neurons and neural circuits over large volumes at high speed and subcellular resolution is a difficult task. Incorporating a Bessel focus module into a two-photon fluorescence mesoscope, we achieved rapid volumetric imaging of neural activity over the mesoscale with synaptic resolution. We applied the technology to calcium imaging of entire dendritic spans of neurons as well as neural ensembles within multiple cortical regions over two hemispheres of the awake mouse brain.

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