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1 Janelia Publications

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    01/03/20 | The neuropeptide Drosulfakinin regulates social isolation-induced aggression in Drosophila.
    Agrawal P, Kao D, Chung P, Looger LL
    Journal of Experimental Biology. 2020 Jan 03;223(2):. doi: 10.1242/jeb.207407

    Social isolation strongly modulates behavior across the animal kingdom. We utilized the fruit fly to study social isolation-driven changes in animal behavior and gene expression in the brain. RNA-seq identified several head-expressed genes strongly responding to social isolation or enrichment. Of particular interest, social isolation downregulated expression of the gene encoding the neuropeptide (), the homologue of vertebrate cholecystokinin (CCK), which is critical for many mammalian social behaviors. knockdown significantly increased social isolation-induced aggression. Genetic activation or silencing of neurons each similarly increased isolation-driven aggression. Our results suggest a U-shaped dependence of social isolation-induced aggressive behavior on signaling, similar to the actions of many neuromodulators in other contexts.

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