Mapping and manipulating neural circuits in the fly brain.

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Advances in Genetics. 2009;65:79-143. doi: 10.1016/S0065-2660(09)65003-3
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Mapping and manipulating neural circuits in the fly brain. Simpson Lab
Simpson JH
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Abstract

Drosophila is a marvelous system to study the underlying principles that govern how neural circuits govern behaviors. The scale of the fly brain (approximately 100,000 neurons) and the complexity of the behaviors the fly can perform make it a tractable experimental model organism. In addition, 100 years and hundreds of labs have contributed to an extensive array of tools and techniques that can be used to dissect the function and organization of the fly nervous system. This review discusses both the conceptual challenges and the specific tools for a neurogenetic approach to circuit mapping in Drosophila.

PMID: 19615532 [PubMed - indexed for MEDLINE]

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Janelia Authors

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