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Small labs, big science.
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Publications

Podgorski LabSchreiter LabGENIECell and Tissue CultureMolecular BiologyViral Tools
A general approach to engineer positive-going eFRET voltage indicators.
Liu (Zhe) LabLippincott-Schwartz LabCell and Tissue CultureAnatomy and HistologyVivarium
A general method to optimize and functionalize red-shifted rhodamine dyes.
Fly Facility
A programmable sequence of reporters for lineage analysis.
Druckmann LabSvoboda LabGENIE
A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology.
Schreiter Lab
Erasable labeling of neuronal activity using a reversible calcium marker.
Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala.
Hermundstad LabSternson Lab
Hindbrain double-negative feedback mediates palatability-guided food and water consumption.
Rubin LabJayaraman Lab
The neuroanatomical ultrastructure and function of a biological ring attractor.
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Featured

SCIENCE NEWS
05/19/2023
| Teamwork on new glutamate indicator leads to lasting friendship and collaboration
INSTITUTE NEWS
05/11/2023
| STEM pioneer Freeman A. Hrabowski, III, inspires Dialogues audience to change culture of science and education
INSTITUTE NEWS
05/10/2023
| Janelia Executive Director Ron Vale elected to Royal Society
SCIENCE NEWS
05/19/2023
| Teamwork on new glutamate indicator leads to lasting friendship and collaboration
INSTITUTE NEWS
04/19/2023
| Wall of Inspiration reflects science’s known and unsung heroes
SCIENCE NEWS
04/05/2023
| Janelia scientists develop fastest calcium indicators yet
SCIENCE NEWS
04/04/2023
| Newest Voltron sensor powers up its detection of smaller brain cell signals
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Featured Tools and Innovations
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MouseLight NeuronBrowser

A vast neural tracing effort by a team of Janelia scientists has upped the number of fully-traced neurons in the mouse brain by a factor of 10. Researchers can now download and browse the data in three dimensions. 

 Use NeuronBrowser
Hemidriver Drosophila Lines ("Split-halves")

These split-GAL4 driver Drosophila lines allow the generation of cell-type specific gene expression. They are freely available through the Bloomington Stockcenter through a large coordinated effort from Janelia Drosophila Resources and the National Institutes of Health.

 Learn More
Janelia Fluor Dyes

These bright and photostable fluorescent labels enable imaging and tracking of individual molecules inside living cells.

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GCaMP6

The GCaMP6 family of GECIs is a collection of green fluorescent indicator proteins that facilitate the measurement of synaptic calcium signals, enabling reliable detection of neuronal responses in vivo.  The next-generation GCaMP6s, GCaMP6m, and GCaMP6f sensors offer increased sensitivity (single action potential detection in vivo) and improved kinetics.

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CaMPARI

This photoconvertible protein enables imaging of the calcium activity history of large areas and populations of cells.  It is based on EosFP, a fluorescent protein that shows emission changes from green to red upon irradiation with UV light.  It is not restricted to the field of view of a microscope, as during real-time calcium imaging.

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Lattice Light Sheet Microscope

This microscope uses a Bessel beam to illuminate a sample with light sheets that are sufficiently thin to achieve isotropic resolution high-speed 3D fluorescent imaging. The technology can visualize cellular processes in spatiotemporal detail not attainable with other fluorescent microscopy techniques.

 Learn More
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