Super-resolution imaging of the endoplasmic reticulum, a multifaceted organelle within the cell, shows that it’s a tangled web of interconnected tubes, instead of containing flat sheets as previously believed.
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Neuronal cell biology is a new research area at Janelia, supporting scientists investigating the structural and functional details of discrete neurons.
Group leader Joshua Dudman and research scientist Eric Yttri seek to understand the normal role of the basal ganglia, a brain region that is affected in Parkinson's disease, in controlling voluntary movement.
Lauded by Nature Methods for its mission, the Advanced Imaging Center develops cutting-edge imaging technologies and makes them widely accessible, at no cost, to scientists before the instruments are commercially available.
Full neuronal circuit reconstruction demands high resolution and high throughput in all three dimensions. The Hess lab has developed customized 3D FIB-SEM solutions, offering long-term system stability and faster imaging speed in connectomics. This video (2011) shows 0.1% of the fly brain, with recent improvements now putting whole fly brain circuitry within reach.
Our engineers collaborate with Janelia scientists to design customized software-based solutions to scientific obstacles, with top-of-the-line infrastructure providing robust computing power and nearly five petabytes of storage.
Fernando Amat, Philipp Keller, and William Lemon were awarded the prize in the 2014 Olympus BioScapes Digital Imaging Competition for their video that captures the early development of a fruit fly embryo.
Studying fruit fly larvae, Janelia scientists have mapped the entire neural circuit involved in combining vibration and pain sensations used in triggering an escape behavior.
Janelia group leader Albert Lee and his team are studying how neurons respond to new places. In a new study, they examined neuronal activity in rats as they explored an unusually large maze for the first time.