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Innovating research practices and technologies to solve biology’s deepest mysteries.
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Publications

Electron Microscopy
09/13/23 |
3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle
Wang (Meng) Lab
09/07/23 |
Mitochondrial GTP metabolism controls reproductive aging in C. elegans.
Aso Lab
09/18/23 |
Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement
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Featured

SCIENCE NEWS
11/29/2023
| Fighting fruit flies help researchers understand why we stay angry
SCIENCE NEWS
11/20/2023
| Reading the mouse mind from its face: New tool decodes neural activity using facial movements
SCIENCE NEWS
11/02/2023
| Rats have an imagination, new research suggests
SCIENCE NEWS
11/29/2023
| Fighting fruit flies help researchers understand why we stay angry
INSTITUTE NEWS
10/31/2023
| Mindfulness expert Jon Kabat-Zinn guides Dialogues audience to experience the present
INSTITUTE NEWS
10/30/2023
| Janelia collaborates with Johns Hopkins on biomedical sciences graduate program
INSTITUTE NEWS
10/26/2023
| Postdoc Life: What is it like to live and work at Janelia?
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Featured Tools and Innovations
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MouseLight NeuronBrowser

A vast neural tracing effort by a team of Janelia scientists has upped the number of fully-traced neurons in the mouse brain by a factor of 10. Researchers can now download and browse the data in three dimensions. 

 Use NeuronBrowser
Hemidriver Drosophila Lines ("Split-halves")

These split-GAL4 driver Drosophila lines allow the generation of cell-type specific gene expression. They are freely available through the Bloomington Stockcenter through a large coordinated effort from Janelia Drosophila Resources and the National Institutes of Health.

 Learn More
Janelia Fluor Dyes

These bright and photostable fluorescent labels enable imaging and tracking of individual molecules inside living cells.

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GCaMP6

The GCaMP6 family of GECIs is a collection of green fluorescent indicator proteins that facilitate the measurement of synaptic calcium signals, enabling reliable detection of neuronal responses in vivo.  The next-generation GCaMP6s, GCaMP6m, and GCaMP6f sensors offer increased sensitivity (single action potential detection in vivo) and improved kinetics.

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CaMPARI

This photoconvertible protein enables imaging of the calcium activity history of large areas and populations of cells.  It is based on EosFP, a fluorescent protein that shows emission changes from green to red upon irradiation with UV light.  It is not restricted to the field of view of a microscope, as during real-time calcium imaging.

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Lattice Light Sheet Microscope

This microscope uses a Bessel beam to illuminate a sample with light sheets that are sufficiently thin to achieve isotropic resolution high-speed 3D fluorescent imaging. The technology can visualize cellular processes in spatiotemporal detail not attainable with other fluorescent microscopy techniques.

 Learn More
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