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Innovating research practices and technologies to solve biology’s deepest mysteries.
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Publications

Blue-shifted genetically encoded Ca2+ indicator with enhanced two-photon absorption
Closing the Experiment-Modeling-Perturbation Loop in Whole-Brain Neuroscience.
Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching.
Multi-day neuron tracking in high-density electrophysiology recordings using earth mover’s distance
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Featured

SCIENCE NEWS
04/22/2025
| New technique expands tissues so hundreds of biomolecules can be seen inside cells
SCIENCE NEWS
03/31/2025
| New imaging tool maps brain-wide changes in neuronal connections
INSTITUTE NEWS
09/25/2024
| We’re recruiting scientists for AI@HHMI, our new $500 million initiative to embed AI systems throughout every stage of the scientific process.
SCIENCE NEWS
04/22/2025
| New technique expands tissues so hundreds of biomolecules can be seen inside cells
SCIENCE NEWS
03/11/2025
| New method uses DNA barcodes for high throughput RNA and protein detection in deep tissue
SCIENCE NEWS
02/27/2025
| Janelia researchers challenge textbook ideas of how the brain specifies movement
SCIENCE NEWS
02/24/2025
| New imaging method reveals the 3D arrangement of molecules inside cells
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Featured Tools and Innovations
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MouseLight NeuronBrowser

A vast neural tracing effort by a team of Janelia scientists has upped the number of fully-traced neurons in the mouse brain by a factor of 10. Researchers can now download and browse the data in three dimensions. 

 Use NeuronBrowser
Hemidriver Drosophila Lines ("Split-halves")

These split-GAL4 driver Drosophila lines allow the generation of cell-type specific gene expression. They are freely available through the Bloomington Stockcenter through a large coordinated effort from Janelia Drosophila Resources and the National Institutes of Health.

 Learn More
Janelia Fluor Dyes

These bright and photostable fluorescent labels enable imaging and tracking of individual molecules inside living cells.

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GCaMP6

The GCaMP6 family of GECIs is a collection of green fluorescent indicator proteins that facilitate the measurement of synaptic calcium signals, enabling reliable detection of neuronal responses in vivo.  The next-generation GCaMP6s, GCaMP6m, and GCaMP6f sensors offer increased sensitivity (single action potential detection in vivo) and improved kinetics.

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CaMPARI

This photoconvertible protein enables imaging of the calcium activity history of large areas and populations of cells.  It is based on EosFP, a fluorescent protein that shows emission changes from green to red upon irradiation with UV light.  It is not restricted to the field of view of a microscope, as during real-time calcium imaging.

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Lattice Light Sheet Microscope

This microscope uses a Bessel beam to illuminate a sample with light sheets that are sufficiently thin to achieve isotropic resolution high-speed 3D fluorescent imaging. The technology can visualize cellular processes in spatiotemporal detail not attainable with other fluorescent microscopy techniques.

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