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Spruston Lab

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Lab Updates

05/20/18 | Check out our latest paper. Cembrowski et al. use a variety of methods to explore cell-type specific contributions to spatial memory by regionally localized pyramidal neurons in the subiculum. View
02/19/18 | New article published in Nature Neuroscience. Bloss et al. use serial-section TEM and array tomography to show that cortical inputs to the apical tuft dendrites of CA1 pyramidal neurons form specialized 'compound synapses'. View
05/17/17 | Commentary in Neuron about the cellular organization of the hippocampus and the importance of integrating results across multiple methodologies. View.
11/06/17 | This Nature Method's article on new methods of capturing gene expression spotlights work by Mark Cembrowski, a Research Scientist in the Spruston Lab. View
04/22/16 | Our latest RNA-seq paper (eLife) describes gene expression in hippocampal principal neurons and introduces a user-friendly web interface (Hipposeq).
03/06/16 | New array tomography paper published in Neuron. View.
01/20/16 | New RNA-seq article published in Neuron. View. With a nice Preview by Tushev and Schuman. View.
11/25/15 | Review article published in Nature Neuroscience. View.
08/06/15 | Paper published in eLife. View.
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We study the function of neurons (and recently glia) in the hippocampus. This structure is a nexus of behaviorally relevant information arriving from many brain areas. These external representations are combined with internal representations of recent experiences—short-term memories—to generate output that is distributed to other brain areas, in order to adaptively guide behavior and form long-term memories. The goal of our lab is to understand how different hippocampal cell types communicate with their synaptic partners within and outside of the hippocampal circuit, altering their activity and connections as a function of experience.

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The brain seems to be made up of a bewildering complexity of parts, and the cells within the parts seem to be characterized by an inscrutable complexity of form, extent, and relationships with each other.

Gordon M. Shepherd

The Synaptic Organization of the Brain, 2nd ed., 1979.