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The Schreiter lab is currently developing tools for permanently marking and selectively manipulating populations of active neurons in model organisms. These tools will bridge anatomy and function for dissection of neuronal circuits.
We recently engineered a genetically encoded integrator of calcium signaling in neurons, called CaMPARI, which allows permanent marking of neurons that were active during a short light pulse.
CaMPARI was validated in mouse cortex, adult and larval Drosophila, as well as larval zebrafish. The manuscript describing this new tool can be found here: