Pairing scientists with engineers and technical specialists, project teams embody Janelia’s collaborative culture and allow us to tackle problems that are unattainable by individual investigators or by incremental progress. These synergistic teams are purposefully flexible and responsive, and thus able to move quickly to meet new research needs and opportunities: a team science approach.
Within the Project Team ecosystem at Janelia, we pursue Large and Small Projects that have specific and targeted goals and produce resources that benefit scientists at Janelia and beyond. We also support Consortia that bring together experts in diverse areas to develop novel ways of answering biological questions, often leveraging technology developed at Janelia.
- FlyEM (Electron Microscopic Reconstructing of the Drosophila Nervous System) aims to develop a fully detailed, cellular- and synaptic-resolution map of the central nervous system of Drosophila melanogaster.
- FlyLight (Optical Mapping of the Fly Nervous System) aims to construct a digital atlas of the Drosophila nervous system with “cell-type-specific resolution” at light-level resolution as well as a collection of “cell-type-specific” driver lines.
- FlyTEM aims to image and assemble the entire CNS of two fruit flies, one from a male and the other from a female, and provide software tools to extract skeletons of neuroanatomical structures in these datasets.
- GENIE (Genetically-Encoded Neuronal Indicator and Effector) aims to develop the next generation of genetically-encoded calcium and voltage sensors with improved temporal precision and increased florescence.
- MouseLight (Mouse Projections and Connections) aims to generate axonal collateral maps of individual neurons across the entire mouse brain using high-speed, high-resolution light microscopy.
- Fly Descending Interneuron aims to anatomically characterize and create cell-type specific driver lines for all ~350 descending interneuron cell types and to understand the role these cells play in sensory guided behavioral circuits.
- Fly Functional Connectome is using optogenetics to probe the synaptic connections of the Drosophila nervous system with a goal of creating an atlas of neural connections.
- TIC (Transcription Imaging Consortium) aims to develop new methods to study the assembly, dynamics and functional regulation of the transcription machinery in live cells at the resolution of a single molecule.
- NeuroSeq (Genetic Profiling of Neurons 2012-2015) characterized the transcriptional state of defined neuron types of biological interest in both the fly and the mouse.
- Larval Olympiad (2012-2015) identified and assayed neuron classes in fruit fly larva that are involved in sensory processing, motor pattern generation, and sensory-motor transformations.
- Fly Olympiad (2009-2012): Developed high-throughput quantitative behavioral assays and conducted a neurogenic screen of ~2,500 Generation 1 Gal4 driver lines. The assays and techniques remain an important part of the science at Janelia and now reside in our Project Team Technical Resources.
Select Team Papers
A platform for brain-wide imaging and reconstruction of individual neurons
eLife. 2016 Jan 20;5. doi: 10.7554/eLife.10566
A visual motion detection circuit suggested by Drosophila connectomics
Nature. August, 2013;500(7461):175–181. doi: 10.1038/nature12450
Ultrasensitive fluorescent proteins for imaging neuronal activity
Nature. August, 2013;499():295-300. doi: 10.1038/nature12354