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We use protein engineering to develop chemical biology tools at the “transcellular” level: to focus on populations of cells, their signaling and metabolite exchange processes, migration patterns, and interactions with other cell types, intruders, and their environment.
The interactions of different types of cells and their mediation by extracellular structures has been an under-addressed target of chemical biology, yet presents unique protein engineering challenges.
Projects in the lab focus on tools that can be useful in this milieu. The lab is broadly interested in 1) developing protein engineering techniques and 2) using protein engineering and chemical biology to sense and manipulate biological processes. We are currently exploring projects related to:
- Affinity reagents
- Manipulation of enzyme activity
- Manipulation and detection of cell-cell and cell-matrix interactions
Interested in joining the team?
We have opportunities for postdoctoral researchers, PhD students (through the Johns Hopkins / Janelia graduate program, or graduate research fellowship program), and undergraduate students (through the Janelia Undergraduate Scholars summer program).
For inquiries email firstname.lastname@example.org.