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Current Opinion in Genetics & Development. 2014 Apr 25;25:1-7. doi: 10.1016/j.gde.2013.10.014
Manipulating nuclear architecture.
Deng W, Blobel GA
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Abstract
The eukaryotic genome is highly organized in the nucleus. Genes can be localized to specific nuclear compartments in a manner reflecting their activity. A plethora of recent reports has described multiple levels of chromosomal folding that can be related to gene-specific expression states. Here we discuss studies designed to probe the causal impact of genome organization on gene expression. The picture that emerges is that of a reciprocal relationship in which nuclear organization is not only shaped by gene expression states but also directly influences them.
PMID: 24584091 [PubMed - indexed for MEDLINE]
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Janelia Authors
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