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Atomic resolution structure determination by the cryo-EM method MicroED.

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Protein Science : a Publication of the Protein Society. 2016 Jul 25;26(1):8-15. doi: 10.1002/pro.2989
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Atomic resolution structure determination by the cryo-EM method MicroED. Gonen Lab
Liu S, Hattne J, Reyes FE, Sanchez-Martinez S, de la Cruz MJ, Shi D, Gonen T
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Abstract

The electron cryo-microscopy (cryoEM) method MicroED has been rapidly developing. In this review we highlight some of the key steps in MicroED from crystal analysis to structure determination. We compare and contrast MicroED and the latest X-ray based diffraction method the X-ray free electron laser (XFEL). Strengths and shortcomings of both MicroED and XFEL are discussed. Finally, all current MicroED structures are tabulated with a view to the future. This article is protected by copyright. All rights reserved.

PMID: 27452773 [PubMed - indexed for MEDLINE]

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