Beyond Breathing: Lung as a Sensory Organ: A Report from the NHLBI Workshop on Lung Sensing and its Implication in Diseases.

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Am J Respir Cell Mol Biol. 2026 Jun 09;. doi: 10.1093/ajrcmb/aanag111
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Beyond Breathing: Lung as a Sensory Organ: A Report from the NHLBI Workshop on Lung Sensing and its Implication in Diseases. Liu (Yin) Lab
Jendzjowsky N, Kuo CS, Reznikov LR, Chen Z, Li P, Prescott S, Liu Y, Seeholzer L, Tschumperlin DJ, Taylor-Clark TE, Rajagopal J, Haber AL, Noël A, Kotas M, Drake M, Pabelick C, Rosenblatt J, Mouradian G, Su Y, Gomez C, Lin Q, Lu Q, Mongodin EF, Vuga L, Zhou G, Prakash YS, Sun X
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Abstract

The lung, one the largest branching organs in our body and vital for survival at first breath, is commonly known as the gas-exchange organ. Recent novel findings on lung sensing cells, molecules, and lung-brain crosstalk in the emerging discipline of interoception have highlighted the consideration of the lung as a sensory organ. Acknowledging the central importance of lung sensing to human health and disease, NHLBI convened a workshop to synthesize the past, current, and future of lung sensing research, with in-person presentations by ∼20 interdisciplinary experts and a large virtual audience. Here, we highlight the key topics discussed and summarize a blueprint for the future in this important field.

PMID: 42265991 [PubMed - indexed for MEDLINE]

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Janelia Authors

Yin Liu
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