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With recent advances in high-throughput Electron Microscopy (EM) imaging it is now possible to image an entire nervous system of organisms like Drosophila melanogaster. One of the bottlenecks to reconstruct a connectome from these large volumes (œ 100 TiB) is the pixel-wise prediction of membranes. The time it would typically take to process such a volume using a convolutional neural network (CNN) with a sliding window approach is in the order of years on a current GPU. With sliding windows, however, a lot of redundant computations are carried out. In this paper, we present an extension to the Caffe library to increase throughput by predicting many pixels at once. On a sliding window network successfully used for membrane classification, we show that our method achieves a speedup of up to 57×, maintaining identical prediction results.