An engineered DNA-binding protein self-assembles metallic nanostructures.

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Chembiochem: A European Journal of Chemical Biology. 2010 Oct 18;11(15):2108-12. doi: 10.1002/cbic.201000407

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An engineered DNA-binding protein self-assembles metallic nanostructures. Gonen Lab

Sedlak R, Hnilova M, Gachelet E, Przybyla L, Dranow D, Gonen T, Sarikaya M, Tamerler C, Traxler B

Note: Research in this publication was not performed at Janelia.

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Abstract

The golden age of DNA: We describe a strategy for engineering bifunctional proteins that simultaneously associate with metals and DNA to create self-assembled nanostructures. A DNA binding protein engineered with a gold binding peptide arranges colloidal gold particles along a DNA guide by virtue of its introduced peptide motif. These self-assembled complexes represent a step toward constructing nanoarchitectures with potential in nanoelectronic and photonic devices.

PMID: 20827792 [PubMed - indexed for MEDLINE]

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An engineered DNA-binding protein self-assembles metallic nanostructures.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 20827792 [PubMed - indexed for MEDLINE]

Janelia Authors