Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons.

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Nature Neuroscience. 2009 Dec;12(12):1485-7. doi: 10.1038/nn.2428
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Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons. Magee LabChklovskii Lab
Makara JK, Losonczy A, Wen Q, Magee JC
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Abstract

The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by localized downregulation of A-type K(+) channel function. Thus, dendritic plasticity might be used to store recent experience in individual branches of the dendritic arbor.

PMID: 19898470 [PubMed - indexed for MEDLINE]

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Janelia Authors

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