Glia instruct developmental neuronal remodeling through TGF-β signaling.

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Nature Neuroscience. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833
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Glia instruct developmental neuronal remodeling through TGF-β signaling.
Awasaki T, Huang Y, O’Connor MB, Lee T
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Abstract

We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

PMID: 21685919 [PubMed - indexed for MEDLINE]

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Janelia Authors

Tzumin Lee
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