Identification of genes controlled by LMX1B in E13.5 mouse limbs.

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Developmental Dynamics: An Official Publication of the American Association of Anatomists. 2010 Aug;239(8):2246-55. doi: 10.1002/dvdy.22357
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Identification of genes controlled by LMX1B in E13.5 mouse limbs.
Gu WX, Kania A
Note: Research in this publication was not performed at Janelia.
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Abstract

During limb development, the dorsal limb mesenchyme expression of the transcription factor LMX1B is required for dorsoventral limb patterning. In mice, Lmx1b mutations result in the mirror-image duplication of ventral limb structures and loss of dorsal limb structures. Heterozygous LMX1B mutations in humans cause the Nail-Patella Syndrome characterized by limb, kidney, and eye developmental defects. We used DNA microarrays to compare the mRNAs in E13.5 mouse Lmx1b mutant and wild-type limbs. We report 14 genes that require Lmx1b for their normal expression in the dorsal limb or the restriction of their expression to the ventral limb.

PMID: 20589901 [PubMed - indexed for MEDLINE]

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