Interplay of DNA repair with transcription: from structures to mechanisms.

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Trends in Biochemical Sciences. 2012 Dec;37(12):543-52. doi: 10.1016/j.tibs.2012.09.002

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Interplay of DNA repair with transcription: from structures to mechanisms. Grigorieff Lab

Deaconescu AM, Artsimovitch I, Grigorieff N

Note: Research in this publication was not performed at Janelia.

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Abstract

Many DNA transactions are crucial for maintaining genomic integrity and faithful transfer of genetic information but remain poorly understood. An example is the interplay between nucleotide excision repair (NER) and transcription, also known as transcription-coupled DNA repair (TCR). Discovered decades ago, the mechanisms for TCR have remained elusive, not in small part due to the scarcity of structural studies of key players. Here we summarize recent structural information on NER/TCR factors, focusing on bacterial systems, and integrate it with existing genetic, biochemical, and biophysical data to delineate the mechanisms at play. We also review emerging, alternative modalities for recruitment of NER proteins to DNA lesions.

PMID: 23084398 [PubMed - indexed for MEDLINE]

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Interplay of DNA repair with transcription: from structures to mechanisms.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 23084398 [PubMed - indexed for MEDLINE]

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