A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA.

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Science. 1987 Mar 6;235(4793):1178-84. doi: 10.1101/gad.1352105
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A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA.
Chang DD, Clayton DA
Note: Research in this publication was not performed at Janelia.
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Abstract

Ribonuclease mitochondrial RNA processing, a site-specific endoribonuclease involved in primer RNA metabolism in mammalian mitochondria, requires an RNA component for its activity. On the basis of copurification and selective inactivation with complementary oligonucleotides, a 135-nucleotide RNA species, not encoded in the mitochondrial genome, is identified as the RNA moiety of the endoribonuclease. This finding implies transport of a nucleus-encoded RNA, essential for organelle DNA replication, to the mitochondrial matrix.

PMID: 2434997 [PubMed - indexed for MEDLINE]

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