In the right place at the right time: visualizing and understanding mRNA localization.

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Nature Reviews Molecular Cell Biology. 2015 Feb;16(2):95-109. doi: 10.1038/nrm3918

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In the right place at the right time: visualizing and understanding mRNA localization. Singer Lab

Buxbaum AR, Haimovich G, Singer RH

Note: Research in this publication was not performed at Janelia.

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Abstract

The spatial regulation of protein translation is an efficient way to create functional and structural asymmetries in cells. Recent research has furthered our understanding of how individual cells spatially organize protein synthesis, by applying innovative technology to characterize the relationship between mRNAs and their regulatory proteins, single-mRNA trafficking dynamics, physiological effects of abrogating mRNA localization in vivo and for endogenous mRNA labelling. The implementation of new imaging technologies has yielded valuable information on mRNA localization, for example, by observing single molecules in tissues. The emerging movements and localization patterns of mRNAs in morphologically distinct unicellular organisms and in neurons have illuminated shared and specialized mechanisms of mRNA localization, and this information is complemented by transgenic and biochemical techniques that reveal the biological consequences of mRNA mislocalization.

PMID: 25549890 [PubMed - indexed for MEDLINE]

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In the right place at the right time: visualizing and understanding mRNA localization.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 25549890 [PubMed - indexed for MEDLINE]

Janelia Authors