A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs.

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Nature Methods. 2017 Jan 31;14(1):45-8
A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs. Eddy/Rivas LabScientific Computing
Rivas E, Clements J, Eddy SR
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Abstract

Many functional RNAs have an evolutionarily conserved secondary structure. Conservation of RNA base pairing induces pairwise covariations in sequence alignments. We developed a computational method, R-scape (RNA Structural Covariation Above Phylogenetic Expectation), that quantitatively tests whether covariation analysis supports the presence of a conserved RNA secondary structure. R-scape analysis finds no statistically significant support for proposed secondary structures of the long noncoding RNAs HOTAIR, SRA, and Xist.

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Janelia Authors

Jody Clements
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