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Neuron. 2014 Feb 5;81:629-40. doi: 10.1016/j.neuron.2013.11.026
Structured synaptic connectivity between hippocampal regions. Druckmann LabMagee Lab
Druckmann Shaul, Feng L, Lee B, Yook C, Zhao T, Magee JC, Kim J
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Abstract
The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.
PMID: 24412418 [PubMed - indexed for MEDLINE]
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Janelia Authors
Shaul Druckmann
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