Synthesis of rhodamines from fluoresceins using Pd-catalyzed C-N cross-coupling.

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Organic Letters. 2011 Dec 16;13(24):6354-7. doi: 10.1021/ol202618t
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Synthesis of rhodamines from fluoresceins using Pd-catalyzed C-N cross-coupling. Lavis Lab
Grimm JB, Lavis LD
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Abstract

A unified, convenient, and efficient strategy for the preparation of rhodamines and N,N’-diacylated rhodamines has been developed. Fluorescein ditriflates were found to undergo palladium-catalyzed C-N cross-coupling with amines, amides, carbamates, and other nitrogen nucleophiles to provide direct access to known and novel rhodamine derivatives, including fluorescent dyes, quenchers, and latent fluorophores.

PMID: 22091952 [PubMed - indexed for MEDLINE]

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Janelia Authors

Jonathan Grimm
Luke Lavis
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