Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation.

janelia7_blocks-janelia7_biblio_header | block

Nature Reviews. Genetics. 2010 Aug;11:549-58. doi: 10.1073/pnas.1100640108

Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation. Tjian Lab

Goodrich JA, Tjian R

Note: Research in this publication was not performed at Janelia.

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

The eukaryotic core promoter recognition complex was generally thought to play an essential but passive role in the regulation of gene expression. However, recent evidence now indicates that core promoter recognition complexes together with ’non-prototypical’ subunits may have a vital regulatory function in driving cell-specific programmes of transcription during development. Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions.

PMID: 20628347 [PubMed - indexed for MEDLINE]

node:body | entity_field

Main Menu (Mobile)- Block

Main Menu - Block

Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 20628347 [PubMed - indexed for MEDLINE]

Janelia Authors