Where to start and when to stop.

Our Research / Publications

janelia7_blocks-janelia7_biblio_header | block

Nature Structural & Molecular Biology. 2006 Aug;13(8):668-70. doi: 10.1038/nsmb0806-668

View Article on

Tian L, Matouschek A

Note: Research in this publication was not performed at Janelia.

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

The activity of a handful of transcription factors, such as mammalian NF-B, Drosophila melanogaster Cubitus interruptus and yeast Spt23 and Mga2, are regulated through partial protein degradation by the proteasome. New data now show that the proteasome activates membrane-bound Spt23 and Mga2 by initiating their proteolysis at an internal site and then degrading the proteins bidirectionally toward both ends of the polypeptide chain, modifying our ideas on how the proteasome degrades targeted substrates.

PMID: 16886005 [PubMed - indexed for MEDLINE]

node:body | entity_field

Main Menu (Mobile)- Block

Main Menu - Block

Where to start and when to stop.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 16886005 [PubMed - indexed for MEDLINE]

Janelia Authors