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Project Teams:
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
2016
Murugesan S, Hong J, Yi J, Li D, Beach JR, Shao L, Meinhardt J, Madison G, Wu X, Betzig E et al..
2016. Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse.. The Journal of Cell Biology. 215(3):383-99.
Legant WR, Shao L, Grimm JB, Brown TA, Milkie DE, Avants BB, Lavis LD, Betzig E.
2016. High-density three-dimensional localization microscopy across large volumes.. Nature Methods.
Zhang X, Zhang M, Li D, He W, Peng J, Betzig E, Xu P.
2016. Highly photostable, reversibly photoswitchable fluorescent protein with high contrast ratio for live-cell superresolution microscopy.. Proceedings of the National Academy of Sciences of the United States of America. 113(37):10364-9.
Wang K, Sun W, Ji N, Betzig E.
2016. in vivo brain imaging with adaptive optical microscope.. Conference on Lasers and Electro-Optics (CLEO): Applications and Technology. :AM40.1.
Nixon-Abell J, Obara CJ, Weigel AV, Li D, Legant WR, Xu CS, H Pasolli A, Harvey K, Hess HF, Betzig E et al..
2016. Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER.. Science (New York, N.Y.). 354(6311):433-46.
Aguet F, Upadhyayula S, Gaudin R, Chou Y-ying, Cocucci E, He K, Chen B-C, Mosaliganti K, Pasham M, Skillern W et al..
2016. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy.. Molecular Biology of the Cell. 27(22):3418-35.
Veltman DM, Williams TD, Bloomfield G, Chen B-C, Betzig E, Insall RH, Kay RR.
2016. A plasma membrane template for macropinocytic cups.. eLife. 5
Li L, Liu H, Dong P, Li D, Legant WR, Grimm JB, Lavis LD, Betzig E, Tjian R, Liu Z.
2016. Real-time imaging of Huntingtin aggregates diverting target search and gene transcription.. eLife. 5
Jung G, Alexander CJ, Wu XS, Piszczek G, Chen B-C, Betzig E, Hammer JA.
2016. V-1 regulates capping protein activity in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 113(43):E6610-9.
2017
Beach JR, Bruun KS, Shao L, Li D, Swider Z, Remmert K, Zhang Y, Conti MA, Adelstein RS, Rusan NM et al..
2017. Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments.. Nature Cell Biology. 19(2):85-93.
Fritz-Laylin LK, Riel-Mehan M, Chen B-C, Lord SJ, Goddard TD, Ferrin TE, Nicholson-Dykstra SM, Higgs H, Johnson GT, Betzig E et al..
2017. Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes.. eLife. 6
Valm AM, Cohen S, Legant WR, Melunis J, Hershberg U, Wait E, Cohen AR, Davidson MW, Betzig E, Lippincott-Schwartz J.
2017. Applying systems-level spectral imaging and analysis to reveal the organelle interactome.. Nature.
Hong J, Murugesan S, Betzig E, Hammer JA.
2017. Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner.. PLoS One. 12(8):e0183174.
Fritzsche M, Fernandes RA, Chang VT, Colin-York H, Clausen MP, Felce JH, Galiani S, Erlenkämper C, Santos AM, Heddleston JM et al..
2017. Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation.. Science Advances. 3(6):e1603032.
Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu T-L, Chen B-C, Betzig E et al..
2017. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.. Science (New York, N.Y.). 356(6338)
2018
Schöneberg J, Dambournet D, Liu T-L, Forster R, Hockemeyer D, Betzig E, Drubin DG.
2018. 4D cell biology: big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell derived intestinal organoids.. Molecular Biology of the Cell. :mbcE18060375.
Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu T-L, Hildebrand DGC, Tsai TY-C, Chen A, Al-Obeidi E, Fass AK, Malhotra S et al..
2018. Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.. eLife. 7
Liu T-L, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J et al..
2018. Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.. Science (New York, N.Y.). 360(6386)
2019
David AF, Roudot P, Legant WR, Betzig E, Danuser G, Gerlich DW.
2019. Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth.. Journal of Cell Biology. 218(7):2150-68.
Colin-York H, Li D, Korobchevskaya K, Chang VT, Betzig E, Eggeling C, Fritzsche M.
2019. Cytoskeletal actin patterns shape mast cell activation.. Communications Biology. 2:93.
Colin-York H, Javanmardi Y, Skamrahl M, Kumari S, Chang VT, Khuon S, Taylor A, Chew T-L, Betzig E, Moeendarbary E et al..
2019. Cytoskeletal control of antigen-dependent T cell activation.. Cell Reports. 26(12):3369-3379.e5.
Turcotte R, Liang Y, Tanimoto M, Zhang Q, Li Z, Koyama M, Betzig E, Ji N.
2019. Dynamic super-resolution structured illumination imaging in the living brain.. Proceedings of the National Academy of Sciences of the United States of America. 116(19):9586-91.