Neuron transplantation partially reverses an obesity disorder in mice.

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Cell Metabolism. 2012 Feb 8;15(2):133-4. doi: 10.1016/j.cmet.2012.01.011
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Neuron transplantation partially reverses an obesity disorder in mice. Sternson Lab
Sternson SM
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Abstract

Mice lacking leptin receptors are grossly obese and diabetic, in part due to dysfunction in brain circuits important for energy homeostasis. Transplantation of leptin receptor-expressing hypothalamic progenitor neurons into the brains of leptin receptor deficient mice led to integration into neural circuits, reduced obesity, and normalized circulating glucose levels.

PMID: 22326215 [PubMed - indexed for MEDLINE]

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Janelia Authors

Scott Sternson
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