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Molecular biology of the cell. 2011 Nov;22(21):3929-32. doi: 10.1091/mbc.E11-05-0452
An evolving paradigm for the secretory pathway? Lippincott-Schwartz Lab
Note: Research in this publication was not performed at Janelia.
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Abstract
The paradigm that the secretory pathway consists of a stable endoplasmic reticulum and Golgi apparatus, using discrete transport vesicles to exchange their contents, gained important support from groundbreaking biochemical and genetic studies during the 1980s. However, the subsequent development of new imaging technologies with green fluorescent protein introduced data on dynamic processes not fully accounted for by the paradigm. As a result, we may be seeing an example of how a paradigm is evolving to account for the results of new technologies and their new ways of describing cellular processes.
PMID: 22039065 [PubMed - indexed for MEDLINE]
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Janelia Authors
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