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Beyene Lab

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Nanoscale sensors report chemical communication between neurons.
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Beyene Lab /

We work at the intersection of materials chemistry and neuroscience to develop and apply nanoscale optical probes to study neurotransmission. Our goal is to expand the neuroscientist’s optical tool kit to sense chemical signaling molecules and to image in the underutilized near-infrared optical window.
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Research Statement

The Beyene Lab develops optical tools to visualize chemical communication in the brain. We work at the interface of materials chemistry, chemical biology, nanotechnology, and neuroscience to design nanoscale fluorescent probes that report on neurotransmitters, neuromodulators, and neurohormones in dissociated cells, intact neural circuits, and living tissue.

A major focus of the lab is the development of near-infrared and short-wave infrared sensors, which offer distinct advantages for imaging in complex biological systems, including improved tissue penetration, reduced background, and compatibility with existing visible-range probes. We aim to build probes that are sensitive, selective, robust, and readily deployable across biological preparations.

We are especially interested in applying these tools to study the neurobiology of monoamine neuromodulators, with a focus on dopamine, norepinephrine, and serotonin. By enabling direct measurements of these chemical signals in space and time, we seek to develop a deeper conceptual understanding of how monoaminergic neurons regulate circuit function, shape behavior, and become disrupted in disease states.

Opportunities

We have opportunities for postdoctoral scholars and graduate and postbaccalaureate students. We’re looking for candidates from diverse backgrounds including neuroscience, chemistry/chemical biology, and the physical sciences, with creativity and passion for toolmaking and the independence to work in a small group.

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Connect with Us

For inquiries, email Abraham at beyenea@janelia.hhmi.org.