2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains

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ACS Bio & Med Chem Au. 2022 Jun 15;2(3):307-12. doi: 10.1021/acsbiomedchemau.1c00068
2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains Lavis LabTool Translation Team (T3)
Banala S, Tkachuk AN, Patel R, Kumar P, Brown TA, Lavis LD
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Abstract

Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we introduce 2,7-diaminobenzopyrylium (DAB) dyes as live-cell mitochondrial stains excited with violet light. This amalgam of the coumarin and rhodamine fluorophore structures yields dyes with high photostability and tunable spectral properties.

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Janelia Authors

Sambashiva Banala
Ariana Tkachuk
Ronak Patel
Pratik Kumar
Tim Brown
Luke Lavis
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