Localized Lysosome Exocytosis Helps Breach Tissue Barriers

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Developmental Cell. 2017 Jul;43:377-378. doi: https://doi.org/10.1016/j.devcel.2017.11.005

Localized Lysosome Exocytosis Helps Breach Tissue Barriers Wang (Shaohe) Lab

Wang Shaohe, Yamada Kenneth

Note: Research in this publication was not performed at Janelia.

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Abstract

Cell invasion across basement membrane barriers is important in both normal development and cancer metastasis. In this issue of Developmental Cell, Naegeli et al. (2017) identify a mechanism for breaching basement membranes. Localized lysosome exocytosis fuels generation of large, invasive cellular protrusions that expand tiny basement membrane openings.

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Localized Lysosome Exocytosis Helps Breach Tissue Barriers

Note: Research in this publication was not performed at Janelia.

Abstract

Janelia Authors