A neural circuit linking learning and sleep in Drosophila long-term memory.

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Nature Communications. 2022 Feb 01;13(1):609. doi: 10.1038/s41467-022-28256-1

A neural circuit linking learning and sleep in Drosophila long-term memory. Keleman LabFly Functional ConnectomeProject Technical ResourcesScientific Computing Systems

Lei Z, Henderson K, Keleman K

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Abstract

Animals retain some but not all experiences in long-term memory (LTM). Sleep supports LTM retention across animal species. It is well established that learning experiences enhance post-learning sleep. However, the underlying mechanisms of how learning mediates sleep for memory retention are not clear. Drosophila males display increased amounts of sleep after courtship learning. Courtship learning depends on Mushroom Body (MB) neurons, and post-learning sleep is mediated by the sleep-promoting ventral Fan-Shaped Body neurons (vFBs). We show that post-learning sleep is regulated by two opposing output neurons (MBONs) from the MB, which encode a measure of learning. Excitatory MBONs-γ2α'1 becomes increasingly active upon increasing time of learning, whereas inhibitory MBONs-β'2mp is activated only by a short learning experience. These MB outputs are integrated by SFS neurons, which excite vFBs to promote sleep after prolonged but not short training. This circuit may ensure that only longer or more intense learning experiences induce sleep and are thereby consolidated into LTM.

PMID: 35105888 [PubMed - indexed for MEDLINE]

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A neural circuit linking learning and sleep in Drosophila long-term memory.

Abstract

PMID: 35105888 [PubMed - indexed for MEDLINE]

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