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Correlated evolution of two copulatory organs via a single cis-regulatory nucleotide change.

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Current Biology : CB. 2018 Oct 05;28(21):3450-7. doi: 10.1016/j.cub.2018.08.047
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Correlated evolution of two copulatory organs via a single cis-regulatory nucleotide change. Stern Lab
Nagy O, Nuez I, Savisaar R, Peluffo AE, Yassin A, Lang M, Stern DL, Matute DR, David JR, Courtier-Orgogozo V
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Abstract

Diverse traits often covary between species [1-3]. The possibility that a single mutation could contribute to the evolution of several characters between species [3] is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophila santomea has evolved additional sex comb sensory teeth on its legs and has lost two sensory bristles on its genitalia. We present evidence that a single nucleotide substitution in an enhancer of the scute gene contributes to both changes. The mutation alters a binding site for the Hox protein Abdominal-B in the developing genitalia, leading to bristle loss, and for another factor in the developing leg, leading to bristle gain. Our study suggests that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits. VIDEO ABSTRACT.

PMID: 30344115 [PubMed - indexed for MEDLINE]

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Janelia Authors

David Stern
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