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janelia7_blocks-janelia7_biblio_header | block
Proceedings of the National Academy of Sciences of the United States of America. 2007 Oct 23;104(43):17192-7. doi: 10.1073/pnas.0707919104
Dendritic spikes induce single-burst long-term potentiation. Spruston Lab
Remy S, Spruston N
janelia7_blocks-janelia7_biblio_abstract | block
Abstract
The hippocampus is essential for episodic memory, which requires single-trial learning. Although long-term potentiation (LTP) of synaptic strength is a candidate mechanism for learning, it is typically induced by using repeated synaptic activation to produce precisely timed, high-frequency, or rhythmic firing. Here we show that hippocampal synapses potentiate robustly in response to strong activation by a single burst. The induction mechanism of this single-burst LTP requires activation of NMDA receptors, L-type voltage-gated calcium channels, and dendritic spikes. Thus, dendritic spikes are a critical trigger for a form of LTP that is consistent with the function of the hippocampus in episodic memory.
PMID: 17940015 [PubMed - indexed for MEDLINE]
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Janelia Authors
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