I grew up near Vancouver, in Richmond, British Columbia, Canada. I was fortunate that my parents didn’t pressure me to pursue any particular career path, so I had the freedom to explore a variety of things before finally deciding to become a neuroscientist. Along the way, I got a great education (see sidebar) and I have been positively influenced by some fantastic mentors and colleagues (see the gallery on our Research Interests page).
I moved to Janelia in 2011 after spending the first 16 years of my academic career in the Neurobiology department at Northwestern University. The environment in that department was outstanding, but I was attracted to Janelia by its unique research environment and the opportunity to contribute to further development of Janelia as a Scientific Program Director, by recruiting new scientific talent, mentoring exceptional young scientists, and catalyzing team projects.
In my lab, we want to understand how the properties of individual neurons contribute to the computational performance of neural circuits controlling cognition and behavior. Most of this computation occurs in dendrites, so much of our work has focused on how structurally and molecularly sophisticated dendritic trees integrate thousands of synaptic inputs to generate action potential firing in the axon. My lab has studied how dendritic excitability is determined by the interactions between dendritic branching and the properties and distributions of dendritic ion channels and synapses, leading to insight concerning the role of backpropagating action potentials and dendritic spikes in synaptic integration and plasticity. We also made the surprising discovery that axons can perform sophisticated integrative functions.
At Janelia, we are continuing this line of work, extending it to examine the integrative function of a variety of genetically defined cell types in the hippocampus. You can learn more at the Spruston Lab website.
The gallery below shows me taking some time out from work to have some fun with my lab members and other colleagues at Janelia.
With my wife, Danette
Great Wall of China
...and Brett Mensh
Jeff Magee, Rhonda Magee, Joel Luethi (back), David Hunt
Spruston lab with the band (Shortness of Breath)
With my wife, Danette