Main Menu (Mobile)- Block

Main Menu - Block

Organizing memories for generalization in complementary learning systems.

Our Research / Publications
janelia7_blocks-janelia7_biblio_header | block
Nature Neuroscience. 2023 Aug 01;26(8):1438-1448. doi: 10.1038/s41593-023-01382-9
View Article on
Organizing memories for generalization in complementary learning systems. Spruston LabFitzgerald Lab
Sun Weinan, Advani Madhu, Spruston Nelson, Saxe Andrew, Fitzgerald James
janelia7_blocks-janelia7_biblio_abstract | block

Abstract

Our ability to remember the past is essential for guiding our future behavior. Psychological and neurobiological features of declarative memories are known to transform over time in a process known as systems consolidation. While many theories have sought to explain the time-varying role of hippocampal and neocortical brain areas, the computational principles that govern these transformations remain unclear. Here we propose a theory of systems consolidation in which hippocampal-cortical interactions serve to optimize generalizations that guide future adaptive behavior. We use mathematical analysis of neural network models to characterize fundamental performance tradeoffs in systems consolidation, revealing that memory components should be organized according to their predictability. The theory shows that multiple interacting memory systems can outperform just one, normatively unifying diverse experimental observations and making novel experimental predictions. Our results suggest that the psychological taxonomy and neurobiological organization of declarative memories reflect a system optimized for behaving well in an uncertain future.

PMID: 37474639 [PubMed - indexed for MEDLINE]

node:body | entity_field

Previous bioRxiv PrePrint https://doi.org/10.1101/2021.10.13.463791

janelia7_blocks-janelia7_biblio_authors | block

Janelia Authors

Weinan Sun
Nelson Spruston
James Fitzgerald
janelia7_blocks-janelia7_biblio_tools | block