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Nat Neurosci. 2005 Jul;8(7):839-41
Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity. Spruston Lab
Note: Research in this publication was not performed at Janelia.
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Abstract
Long-term potentiation and long-term depression require postsynaptic depolarization, which many current models attribute to backpropagating action potentials. New experimental work suggests, however, that other mechanisms can lead to dendritic depolarization, and that backpropagating action potentials may be neither necessary nor sufficient for synaptic plasticity in vivo.
PMID: 16136666 [PubMed - indexed for MEDLINE]
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Janelia Authors
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