Slow integration leads to persistent action potential firing in distal axons of coupled interneurons.

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Nature Neuroscience. 2011 Feb;14(2):200-7. doi: 10.1038/nn.2728

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Slow integration leads to persistent action potential firing in distal axons of coupled interneurons. Spruston Lab

Sheffield ME, Best TK, Mensh BD, Kath WL, Spruston N

Note: Research in this publication was not performed at Janelia.

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Abstract

The conventional view of neurons is that synaptic inputs are integrated on a timescale of milliseconds to seconds in the dendrites, with action potential initiation occurring in the axon initial segment. We found a much slower form of integration that leads to action potential initiation in the distal axon, well beyond the initial segment. In a subset of rodent hippocampal and neocortical interneurons, hundreds of spikes, evoked over minutes, resulted in persistent firing that lasted for a similar duration. Although axonal action potential firing was required to trigger persistent firing, somatic depolarization was not. In paired recordings, persistent firing was not restricted to the stimulated neuron; it could also be produced in the unstimulated cell. Thus, these interneurons can slowly integrate spiking, share the output across a coupled network of axons and respond with persistent firing even in the absence of input to the soma or dendrites.

PMID: 21150916 [PubMed - indexed for MEDLINE]

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Slow integration leads to persistent action potential firing in distal axons of coupled interneurons.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 21150916 [PubMed - indexed for MEDLINE]

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