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- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
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- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
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2025
Rosenthal JS, Zhang D, Yin J, Long C, Yang G, Li Y, Lu Z, Li W-P, Yu Z, Li J et al..
2025. Molecular organization of central cholinergic synapses.. Proc Natl Acad Sci U S A. 122(17):e2422173122.
Zhou H, Hutchings J, Shiozaki M, Zhao X, Doolittle LK, Yang S, Yan R, Jean N, Riggi M, Yu Z et al..
2025. Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography.. Proc Natl Acad Sci U S A. 122(19):e2426449122.
2024
Ackerman D, Avetissian E, Bleck CKE, Bogovic JA, Innerberger M, Korff W, Li W-P, Lu Z, Petruncio A, Preibisch S et al..
2024. Data Release: High-Resolution Imaging and Segmentation of P7 Mouse Tissue Microarchitecture Using FIB-SEM and Machine Learning. bioRxiv.
Hou K, Ge P, Sawaya MR, Dolinsky JL, Yang Y, Jiang YXiao, Lutter L, Boyer D, Cheng X, Pi J et al..
2024. How short peptides can disassemble ultra‐stable tau fibrils extracted from Alzheimer’s disease brain by a strain‐relief mechanismAbstractBackgroundMethodResultConclusion. Alzheimer's & Dementia. 20(S6)
Zhou H, Hutchings J, Shiozaki M, Zhao X, Doolittle LK, Yang S, Yan R, Jean N, Riggi M, Yu Z et al..
2024. Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography. bioRxiv.
2023
Zhang Z, Feng Z, Zhao X, Jean D, Yu Z, Chapman ER.
2023. Functionalization and higher-order organization of liposomes with DNA nanostructures.. Nature Communications. 14(1):5256.
Wright KM, DiNapoli SR, Miller MS, P Azurmendi A, Zhao X, Yu Z, Chakrabarti M, Shi WX, Douglass J, Hwang MS et al..
2023. Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen.. Nature Communications. 14(1):5063.
Chen Z, Greenan GA, Shiozaki M, Liu Y, Skinner WM, Zhao X, Zhao S, Yan R, Yu Z, Lishko PV et al..
2023. In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes.. Nature Structural & Molecular Biology. 30(3):360-9.
2022
Wasmuth EV, Broeck AVanden, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W et al..
2022. Allosteric interactions prime androgen receptor dimerization and activation.. Molecular Cell. 82(11):2021-31.
Shaban NM, Yan R, Shi K, Moraes SN, Cheng AZ, Carpenter MA, McLellan JS, Yu Z, Harris RS.
2022. Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.. Science Advances. 8(17):eabm2827.
Egri SB, Ouch C, Chou H-T, Yu Z, Song K, Xu C, Shen K.
2022. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.. Molecular Cell. 36(1)
Hirano S, Kappel K, Altae-Tran H, Faure G, Wilkinson ME, Kannan S, F Demircioglu E, Yan R, Shiozaki M, Yu Z et al..
2022. Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA.. Nature. 610(7932):575-581.
2021
Caveney NA, Workman SD, Yan R, Atkinson CE, Yu Z, Strynadka NCJ.
2021. CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution.. Nature Communications. 12(1):2775.
Qiu B, Matthies D, Fortea E, Yu Z, Boudker O.
2021. Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport.. Sciences Advances. 7(10)
Fukudome A, Singh J, Mishra V, Reddem E, Martinez-Marquez F, Wenzel S, Yan R, Shiozaki M, Yu Z, Wang JChe-Yen et al..
2021. Structure and RNA template requirements of RNA-DEPENDENT RNA POLYMERASE 2.. Proceedings of the National Academy of Sciences of the U.S.A.. 118(51)
2020
Matthies D, Lee NYJ, Gatera I, H Pasolli A, Zhao X, Liu H, Walpita D, Liu Z, Yu Z, Ioannou MS.
2020. Microdomains form on the luminal face of neuronal extracellular vesicle membranes.. Scientific Reports. 10(1):11953.
He S, Chou H-T, Matthies D, Wunder T, Meyer MT, Atkinson N, Martinez-Sanchez A, Jeffrey PD, Port SA, Patena W et al..
2020. The structural basis of Rubisco phase separation in the pyrenoid.. Nature Plants.
He S, Chou H-T, Matthies D, Wunder T, Meyer MT, Atkinson N, Martinez-Sanchez A, Jeffrey PD, Port SA, Patena W et al..
2020. The structural basis of Rubisco phase separation in the pyrenoid.. Nature Plants. 6(12):1480-1490.
2019
Majewski DD, Worrall LJ, Hong C, Atkinson CE, Vuckovic M, Watanabe N, Yu Z, Strynadka NCJ.
2019. Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.. Nature Communications. 10(1):626.
Shen K, Rogala KB, Chou H-T, Huang RK, Yu Z, Sabatini DM.
2019. Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.. Cell. 179(6):1319-29.
Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang L-Y, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D et al..
2019. Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.. Nature Structural and Molecular Biology. 26(12):1123-1131.
Hu J, Worrall LJ, Vuckovic M, Hong C, Deng W, Atkinson CE, B. Finlay B, Yu Z, Strynadka NCJ.
2019. T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.. Nature Microbiology. 4(11):2010-19.
2018
Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z et al..
2018. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.. Nature. 556(7699):64-9.
Gruszczyk J, Huang RK, Chan L-J, Menant S, Hong C, Murphy JM, Mok Y-F, Griffin MDW, Pearson RD, Wong W et al..
2018. Cryo-EM structure of an essential Plasmodium vivax invasion complex.. Nature. 559(7712):135-139.