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Main Menu - Block
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium

We develop protein-based tools for tissue-level biology and fluorescent biosensors using high-throughput screening methodologies and machine learning.
Two major challenges in bioimaging using biosensors are 1) multiplexing biosensors and 2) the relative dearth of strategies to measure biochemical events at the tissue scale.
Projects in the lab focus on tools that can be useful in this milieu. The lab is broadly interested in 1) developing protein engineering techniques to rapidly and efficiently generate high-performance biosensors and 2) using protein engineering and chemical biology to sense and manipulate metabolism and key biochemical processes occurring in tissues. We are currently exploring projects related to:
- High-throughput assays and machine learning for protein engineering
- Multiplexed fluorescent biosensors
- Detection of protease-related phenomena in complex tissues
Interested in joining the team?
We have opportunities for postdoctoral researchers, PhD students (through the Johns Hopkins / Janelia graduate program, or graduate research fellowship program), and undergraduate students (through the Janelia Undergraduate Scholars summer program).
For inquiries email teboa@janelia.hhmi.org.