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Innovating research practices and technologies to solve biology’s deepest mysteries.
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Publications

Blue-shifted genetically encoded Ca2+ indicator with enhanced two-photon absorption
Closing the Experiment-Modeling-Perturbation Loop in Whole-Brain Neuroscience.
Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching.
Multi-day neuron tracking in high-density electrophysiology recordings using earth mover’s distance
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Featured

SCIENCE NEWS
10/24/2024
| New tool helps scientists spot patterns in mountains of data
RESEARCH NEWS
10/03/2024
| Small brains can accomplish big things, according to new theoretical research
INSTITUTE NEWS
09/25/2024
| We’re recruiting scientists for AI@HHMI, our new $500 million initiative to embed AI systems throughout every stage of the scientific process.
SCIENCE NEWS
10/24/2024
| New tool helps scientists spot patterns in mountains of data
SCIENCE NEWS
09/20/2024
| New biosensor illuminates physiological signals in living animals
SCIENCE NEWS
09/11/2024
| Researchers combine the power of AI and the connectome to predict brain cell activity
NEWS
09/05/2024
| Decoding the language of cells with the power of proteomics
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Featured Tools and Innovations
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MouseLight NeuronBrowser

A vast neural tracing effort by a team of Janelia scientists has upped the number of fully-traced neurons in the mouse brain by a factor of 10. Researchers can now download and browse the data in three dimensions. 

 Use NeuronBrowser
Hemidriver Drosophila Lines ("Split-halves")

These split-GAL4 driver Drosophila lines allow the generation of cell-type specific gene expression. They are freely available through the Bloomington Stockcenter through a large coordinated effort from Janelia Drosophila Resources and the National Institutes of Health.

 Learn More
Janelia Fluor Dyes

These bright and photostable fluorescent labels enable imaging and tracking of individual molecules inside living cells.

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GCaMP6

The GCaMP6 family of GECIs is a collection of green fluorescent indicator proteins that facilitate the measurement of synaptic calcium signals, enabling reliable detection of neuronal responses in vivo.  The next-generation GCaMP6s, GCaMP6m, and GCaMP6f sensors offer increased sensitivity (single action potential detection in vivo) and improved kinetics.

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CaMPARI

This photoconvertible protein enables imaging of the calcium activity history of large areas and populations of cells.  It is based on EosFP, a fluorescent protein that shows emission changes from green to red upon irradiation with UV light.  It is not restricted to the field of view of a microscope, as during real-time calcium imaging.

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Lattice Light Sheet Microscope

This microscope uses a Bessel beam to illuminate a sample with light sheets that are sufficiently thin to achieve isotropic resolution high-speed 3D fluorescent imaging. The technology can visualize cellular processes in spatiotemporal detail not attainable with other fluorescent microscopy techniques.

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