Hidden Markov model speed heuristic and iterative HMM search procedure.

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BMC Bioinformatics. 2010;11:431. doi: 10.1186/1471-2105-11-431
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Hidden Markov model speed heuristic and iterative HMM search procedure. Eddy/Rivas Lab
Johnson LS, Eddy SR, Portugaly E
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Abstract

Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require considerable time to search large sequence databases.

PMID: 20718988 [PubMed - indexed for MEDLINE]

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Janelia Authors

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