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Publications

Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal.
Imaging neuronal voltage beyond the scattering limit
Multiplex Detection of Gene Expression in the Intact Drosophila Brain Using Expansion-Assisted Iterative Fluorescence In Situ Hybridization.
Accelerating Neuron Reconstruction with PATHFINDER
Proprioceptive limit detectors mediate sensorimotor control of the Drosophila leg
Neuronal growth patterns and synapse formation are mediated by distinct activity-dependent mechanisms.
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Featured

SCIENCE NEWS
11/11/2025
| Turning the gut microbiome into a longevity factory
SCIENCE NEWS
11/10/2025
| New research shows how cells orchestrate protein production
SCIENCE NEWS
10/06/2025
| Researchers reveal connectome of the male fruit fly central nervous system
SCIENCE NEWS
11/11/2025
| Turning the gut microbiome into a longevity factory
SCIENCE NEWS
09/25/2025
| Leaving a mark: New research shows how longevity is inherited across generations
SCIENCE NEWS
09/16/2025
| Unleashing the GENIE: Janelia’s Project Team develops state-of-the-art sensors for biological research
SCIENCE NEWS
08/27/2025
| Researchers detail how neurotransmitter receptors in the fly brain change during development
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Featured Tools and Innovations
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MouseLight NeuronBrowser

A vast neural tracing effort by a team of Janelia scientists has upped the number of fully-traced neurons in the mouse brain by a factor of 10. Researchers can now download and browse the data in three dimensions. 

 Use NeuronBrowser
Hemidriver Drosophila Lines ("Split-halves")

These split-GAL4 driver Drosophila lines allow the generation of cell-type specific gene expression. They are freely available through the Bloomington Stockcenter through a large coordinated effort from Janelia Drosophila Resources and the National Institutes of Health.

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Janelia Fluor Dyes

These bright and photostable fluorescent labels enable imaging and tracking of individual molecules inside living cells.

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GCaMP6

The GCaMP6 family of GECIs is a collection of green fluorescent indicator proteins that facilitate the measurement of synaptic calcium signals, enabling reliable detection of neuronal responses in vivo.  The next-generation GCaMP6s, GCaMP6m, and GCaMP6f sensors offer increased sensitivity (single action potential detection in vivo) and improved kinetics.

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CaMPARI

This photoconvertible protein enables imaging of the calcium activity history of large areas and populations of cells.  It is based on EosFP, a fluorescent protein that shows emission changes from green to red upon irradiation with UV light.  It is not restricted to the field of view of a microscope, as during real-time calcium imaging.

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Lattice Light Sheet Microscope

This microscope uses a Bessel beam to illuminate a sample with light sheets that are sufficiently thin to achieve isotropic resolution high-speed 3D fluorescent imaging. The technology can visualize cellular processes in spatiotemporal detail not attainable with other fluorescent microscopy techniques.

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