Multimodal in vivo brain electrophysiology with integrated glass microelectrodes.

janelia7_blocks-janelia7_biblio_header | block

Nature Biomedical Engineering. 2019 Apr 01;3(9):741-53. doi: 10.1038/s41551-019-0373-8

Multimodal in vivo brain electrophysiology with integrated glass microelectrodes. Lee (Albert) LabHarris LabSpruston LabJanelia Experimental Technology

Hunt DL, Lai C, Smith RD, Lee AK, Harris TD, Barbic M

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

Electrophysiology is the most used approach for the collection of functional data in basic and translational neuroscience, but it is typically limited to either intracellular or extracellular recordings. The integration of multiple physiological modalities for the routine acquisition of multimodal data with microelectrodes could be useful for biomedical applications, yet this has been challenging owing to incompatibilities of fabrication methods. Here, we present a suite of glass pipettes with integrated microelectrodes for the simultaneous acquisition of multimodal intracellular and extracellular information in vivo, electrochemistry assessments, and optogenetic perturbations of neural activity. We used the integrated devices to acquire multimodal signals from the CA1 region of the hippocampus in mice and rats, and show that these data can serve as ground-truth validation for the performance of spike-sorting algorithms. The microdevices are applicable for basic and translational neurobiology, and for the development of next-generation brain-machine interfaces.

PMID: 30936430 [PubMed - indexed for MEDLINE]

node:body | entity_field

janelia7_blocks-janelia7_biblio_authors | block

janelia7_blocks-janelia7_biblio_tools | block

Main Menu (Mobile)- Block

Main Menu - Block

Multimodal in vivo brain electrophysiology with integrated glass microelectrodes.

Abstract

PMID: 30936430 [PubMed - indexed for MEDLINE]

Janelia Authors