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42 Publications

Showing 41-42 of 42 results
Rubin LabAso LabFlyLight
12/23/14 | The neuronal architecture of the mushroom body provides a logic for associative learning.
Aso Y, Hattori D, Yu Y, Johnston RM, Iyer NA, Ngo T, Dionne H, Abbott L, Axel R, Tanimoto H, Rubin GM
eLife. 2014 Dec 23;3:. doi: 10.7554/eLife.04577

We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell-MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.

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Aso LabRubin Lab
03/01/20 | Toward nanoscale localization of memory engrams in Drosophila.
Aso Y, Rubin GM
Journal of Neurogenetics. 2020 Mar 01;34(1):151-55. doi: 10.1080/01677063.2020.1715973

The Mushroom Body (MB) is the primary location of stored associative memories in the Drosophila brain. We discuss recent advances in understanding the MB's neuronal circuits made using advanced light microscopic methods and cell-type-specific genetic tools. We also review how the compartmentalized nature of the MB's organization allows this brain area to form and store memories with widely different dynamics.

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