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    01/16/04 | Transformation of olfactory representations in the Drosophila antennal lobe.
    Wilson RI, Turner GC, Laurent G
    Science (New York, N.Y.). 2004 Jan 16;303(5656):366-70. doi: 10.1126/science.1090782

    Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.

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