Filter
Associated Lab
- Ahrens Lab (1) Apply Ahrens Lab filter
- Betzig Lab (1) Apply Betzig Lab filter
- Cardona Lab (1) Apply Cardona Lab filter
- Grigorieff Lab (3) Apply Grigorieff Lab filter
- Hess Lab (1) Apply Hess Lab filter
- Jayaraman Lab (1) Apply Jayaraman Lab filter
- Keleman Lab (1) Apply Keleman Lab filter
- Lavis Lab (1) Apply Lavis Lab filter
- Li Lab (1) Apply Li Lab filter
- Lippincott-Schwartz Lab (3) Apply Lippincott-Schwartz Lab filter
- Liu (Zhe) Lab (2) Apply Liu (Zhe) Lab filter
- Looger Lab (2) Apply Looger Lab filter
- Pachitariu Lab (1) Apply Pachitariu Lab filter
- Schreiter Lab (1) Apply Schreiter Lab filter
- Stern Lab (1) Apply Stern Lab filter
- Stringer Lab (2) Apply Stringer Lab filter
- Svoboda Lab (2) Apply Svoboda Lab filter
- Tebo Lab (1) Apply Tebo Lab filter
- Truman Lab (1) Apply Truman Lab filter
- Wang (Shaohe) Lab (1) Apply Wang (Shaohe) Lab filter
Publication Date
- June 27, 2019 (4) Apply June 27, 2019 filter
- June 26, 2019 (4) Apply June 26, 2019 filter
- June 25, 2019 (1) Apply June 25, 2019 filter
- June 21, 2019 (5) Apply June 21, 2019 filter
- June 17, 2019 (1) Apply June 17, 2019 filter
- June 15, 2019 (1) Apply June 15, 2019 filter
- June 14, 2019 (2) Apply June 14, 2019 filter
- June 11, 2019 (1) Apply June 11, 2019 filter
- June 10, 2019 (1) Apply June 10, 2019 filter
- June 6, 2019 (1) Apply June 6, 2019 filter
- June 1, 2019 (1) Apply June 1, 2019 filter
- Remove June 2019 filter June 2019
- Remove 2019 filter 2019
Type of Publication
22 Publications
Showing 21-22 of 22 resultsAnimal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system.
Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia protein M1 Spastin, a membrane-bound AAA ATPase found on LDs, coordinates fatty acid (FA) trafficking from LDs to peroxisomes through two inter-related mechanisms. First, M1 Spastin forms a tethering complex with peroxisomal ABCD1 to promote LD-peroxisome contact formation. Second, M1 Spastin recruits the membrane-shaping ESCRT-III proteins IST1 and CHMP1B to LDs via its MIT domain to facilitate LD-to-peroxisome FA trafficking, possibly through IST1 and CHMP1B modifying LD membrane morphology. Furthermore, M1 Spastin, IST1 and CHMP1B are all required to relieve LDs of lipid peroxidation. The roles of M1 Spastin in tethering LDs to peroxisomes and in recruiting ESCRT-III components to LD-peroxisome contact sites for FA trafficking may help explain the pathogenesis of diseases associated with defective FA metabolism in LDs and peroxisomes.