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Reconstructing an Animal’s Development Cell by Cell

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08/18/14 | Reconstructing an Animal’s Development Cell by Cell

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Janelia researchers have developed a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal’s body plan one cell at a time. The method can be used to rapidly track the three-dimensional movements of cells in data-rich images.

Philipp Keller, a group leader at Janelia, led the team that developed the computational framework. He and his colleagues, including Janelia postdoc Fernando Amat, Janelia group leader Kristin Branson and former Janelia lab head Eugene Myers, who is now at the Max Plank Institute of Molecular Cell Biology and Genetics, have used the method to reconstruct cell lineage during development of the early nervous system in a fruit fly. Their method can be used to trace cell lineages in multiple organisms and efficiently processes data from multiple types of fluorescent microscopes.

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Read the full article on HHMI.org

Read more about Philipp Keller's research

Read more about Kristin Branson's research