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Mark Eddison

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People / Mark EddisonProject Technical Resources
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Research Specialist
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Current Research:

Project Technical Resources
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Expansion Microscopy and mFISH technology development

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Biography

I received my PhD in developmental biology from the ICRF/UCL, under Julian Lewis examining the role of Notch signaling chick inner ear development. I completed my post-doctoral training under Ulrike Heberlein at UCSF. Here I discovered that synapse number is a mechanism that regulates alcohol sensitivity in flies. This study lead me to my interest in the genetic regulation of the effects of social isolation (aggression, activity and alcohol resistance) which I pursued as a staff scientist in the Heberlein Lab at Janelia in 2013.  In 2017, I joined the Project Technical Resource team. Here, I principally work with Paul Tillberg and Scott Sternson on developing technology to visualize RNA expression, at the level of single molecules, of up to 50 different genes in the same piece of expanded tissue. 

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Featured Publications

06/09/11 arouser reveals a role for synapse number in the regulation of ethanol sensitivity.
A reduced sensitivity to the sedating effects of alcohol is a characteristic associated with alcohol use disorders (AUDs). A genetic screen for ethanol sedation mutants in Drosophila identified arouser (aru), which functions in developing neurons to reduce ethanol sensitivity. Genetic evidence suggests that aru regulates ethanol sensitivity through its activation by Egfr/Erk signaling and its inhibition by PI3K/Akt signaling. The aru mutant also has an increased number of synaptic terminals in the larva and adult fly.