FlyTEM

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FlyTEM /

The FlyTEM project imaged and assembled the entire CNS of two fruit flies, one from a male and the other from a female, and provide software tools to extract skeletons of neuroanatomical structures in these datasets.

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Our Research

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Electron microscopy has sufficient resolution to identify all the neurons in a given image stack and the chemical synapses between them, but historically it has been limited to small volumes. With recent improvements in serial section transmission EM hardware and software, EM volumes encompassing a full adult central nervous system of the fruit fly Drosophila melanogaster are now within reach. These EM volumes enabled neuronal circuit mapping efforts spanning the entire brain of this important model organism, and are likely to contribute to substantial advances in neurobiology overall.

Cross-section through an entire adult female fruit-fly brain imaged by ssTEM and fully assembled.
Bar: 100 micron

These EM volumes enabled neuronal circuit mapping efforts spanning the entire brain of this important model organism and are likely to contribute to substantial advances in neurobiology overall.

Brain-spanning CATMAID tracing of olfactory projection neurons (reds) and their post-synaptic Kenyon cells (greens)

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FlyTEM

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