Development of an adrenocortical cell model of calcium signaling modulation to decipher the molecular mechanisms responsible for primary aldosteronism

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Archives of Cardiovascular Diseases Supplements. 2022 Jun 01;14(2):160. doi: 10.1016/j.acvdsp.2022.04.153

Development of an adrenocortical cell model of calcium signaling modulation to decipher the molecular mechanisms responsible for primary aldosteronism Sternson Lab

BakhtaFedlaoui , Cosentino Teresa, Sayed Zeina, Giscos-Douriez Isabelle, Fernandes-Rosa Fabio, -SébastienHulot Jean, Magnus Chris, Sternson Scott, Zennaro Maria, Boulkroun Sheerazed

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Abstract

Primary aldosteronism (PA) is the most frequent form of secondary hypertension. The identification of germline or somatic mutations in different genes coding for ion channels and defines PA as a channelopathy. These mutations promote activation of calcium signaling, the main trigger for aldosterone biosynthesis.

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Development of an adrenocortical cell model of calcium signaling modulation to decipher the molecular mechanisms responsible for primary aldosteronism

Abstract

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